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ResveratrolLuteinAstaxanthinPhosphatidylserineNatural Vitamin k2Grape seed Extract

Grape seed Extract

  • Raw material-grape seed import from France

  • Grape seed extract powder

  • 1-5kg packing by aluminum foil bag

  • 10-25kg packing by fiber drum

Brand:NINO TM

Product code:G11002

Product Specifications:Polyphenols 90-95%,OPCs95%

Latin Name: Vitis vinifera L.

Active ingredients: Proanthocyanidins,polyphenols

Test Method: UV/HPLC

Free Sample: Available

Availability: In Stock

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Product description

Name: Grape seed Extract
Source: Vitis vinifera L.
Part used: Seed

Specification: 
a. Proanthocyanidins >95%(UV,Bate-smith),Proanthocyanidins B2>1.8%(HPLC), Oligomers >60%(HPLC)
b.Proanthocyanidins > 95%(UV,Bate-smith), ORAC>15000 μmoleTE/g (BRUNSWICK REPORT),Polyphenols>95%( UV, 280nm/catechin)
c.Proanthocyanidins > 95%(UV,Bate-smith), Polyphenols>95%( UV, 280nm/catechin)
d.polyphenols85%( Folin-C/Gallic acid)
e.b.Proanthocyanidins > 95% (UV,Bate-smith)
Packing: 1kg/foil bag, 5kg/foil bag, 10kg/foil bag, 25kg/drum

Proanthocyanidins come in a multitude of chemical structures and sizes consisting of base units called "monomers." Proanthocyanidins containing two or more monomers chemically linked together are called oligomeric proanthocyanidins or "OPCs." OPCs containing two monomers are called dimers, three monomers are called trimers, four are called tetramers, five pentamers, etc.To illustrate the complexity of the compounds that exist in grape seed extracts, consider this: There are basically three proanthocyanidin monomers called "catechin" "gallic acid"and "epicatechin."
                    

     gallic acid                                              catechin                                                    epicatechin

Each of these bind at either the alpha or beta position on their molecular structures to form dimers, trimers, etc. In addition, catechin and epicatechin can also form numerous esters from gallic acid, called catechin or epicatechin "gallate",as well as various sugar and protein molecules called "glycosides" and "peptides", respectively. In fact, the total number of possible dimers, including gallic acid and glucose esters alone, are 162. And each time you add an additional monomer, the total number of possible combinations increases geometrically; trimers jump to over 550, tetramers over 1,200,etc. As below are two kinds of dimers:

     


                               b1                                                                        b2

Oligomeric proanthocyanidins contain dimers,trimers,tetramers.
The complexity of OPCs, as well as the diverging interests of many of the companies who sell grape seed extracts, underscores the difficulty the Grape Seed Extract Committee has had in defining OPCs. Quite literally, OPCs consist of two or moreproanthocyanidin monomers. However,this definition would include long chains of monomers called polymers and condensed tannins. Some parties believe that polymers and tannins should not be considered OPCs. Others feel differently. In addition, there is general disagreement in defining what a polymeris. Five or more monomers? Seven or more? Ten or more?Although there is evidence to suggest that smaller OPCs, such as dimers, trimers and tetramers, are more soluble and bioavailable than larger OPCs, there is also evidence to suggest that less soluble polymers and tannins are beneficial as well. Recently, Hagerman,et al., have shown that polymeric proanthocyanidins and tannins are 15 to 30times more effective at quenching free radicals than are simple polyphenols. Since polymers and tannins are not well absorbed, the researchers suggest that they could exert their antioxidant activity within the digestive tract to protect lipids, proteinsand carbohydrates from oxidative damage during digestion, and spare absorbable antioxidants such as vitamins E, C and beta-carotene.

High performance liquid chromatogram of our Grape seed Extract
Function
Studies have shown the antioxidant activity of these specific bioflavonoids is 20 to 50 times greater than Beta-Carotene or Vitamins C and E at scavenging specific free radicals. By nourishing blood vessel walls and performing other renewing functions, grape seed extract helps promote healthy blood pressure levels, heart health, and a proper inflammation response.

System
Health care efficacy
Free radical damage
Anti-cardiopathy
Anti-cancer
Prevent arthritis
Postpone aging
Prevent over 70% diseases related to the free radicals.
Blood vessel
Keep proper penetrability of capillary vessel.
Reduce fragility of capillary vessel.
Relief the damage caused by sport, alleviate edema and swelling of leg.
Has the treatment of the damage and defection of Chronic vein, and help phlebitis.
Red cell
Increase the flexible of the membrane of the red cells.
Skin health
Increase elasticity, smoothness of skin.
Prevent psoriasis and damage from sunshine.
Hypersusceptibility
Has outstanding function of preventing hay fever.
Increase flexibility of joint.
Relief pain of swell of joint.
Diabetes
Alleviate diabetic retinopathy.
Eye disease
Help retinopathy.
Prevent capillary vessel bleeding
Gastric & intestines disease
Prevent gastric ulcer and gastritis


Safety
a. LD50 (bandicoot and mouse)=4000mg/kg;
b. There is no side effect, teratogenesis or mutagenesis after being taken 6 months by bandicoot 60mg/kg·d or 12 months by dog with the same dosage, and has good tolerance;
c. Very safe to be taken by female animals when and after pregnancy.

Technical Docments:

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Related Article:

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